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Oncotarget is a free to access online journal that tackles various scientific researches and results. It is published weekly by the Impact Journals. It is also accessible in print upon special requests. The journal’s mission is to ensure scientific findings reach to as many people as possible. What the journal publishes is always reviewed by other peer scientists, a strategy that makes the information reliable. By being an online journal, the information is shared quickly ensuring that it is timely in fighting diseases. Oncotaget has managed to bridge the gap between different sectors while allowing all researchers to contribute to the growth of science by Mikhail Blagosklonny. The organization’s ultimate goal is for everyone to live in a world that is free of diseases.

Diet Restriction for Cellular Rejuvenation

One of the papers published by Oncotarget is on the nutritional perspective on cellular rejuvenation. Lifespan can be extended and aging process decelerated by restricting dietary energy intake. Most people confuse dietary restriction with calorie restriction. The two, however, have some significant differences. Dietary restriction involves decreasing the amount of food allocated. Calorie restriction means altering the nutritional composition thereby reducing the energy component of the food. In the study, mice fed on dietary restriction were let to undergo some fasting periods. These periods are believed to have effects on the extension of the lifespan. During fasting, the nutrient-sensing anabolic pathway is deactivated, which is a reason for lifespan prolonging effect. The indicator in play here is the inhibition of mTOR activity.

The Findings

mTOR is a pathway that promotes growth, which is triggered by the circulation of amino acids, insulin, and other growth factors. It, however, inhibits autophagy and enhances metabolic derangement, counteracting cellular cleansing. mTOR hyper activation can, however, cause aging. On the other hand, overeating, ad libitum feeding, can grow an aging phenotype as evidenced by mice that were obese after being overfed. The accelerated aging was also seen after feeding them with diets that had more energy. The use of diet restriction on a diet- induced obese mice caused an abolishment of the mTOR pathway. The chaperone-mediated autophagy that usually declines with age was also induced. The end finding was that diet restriction leads to cellular rejuvenation.

MB2 Dental continues to advance its scope of services that encourage dentists in efficiently running each and every aspect of their practice.With more than 70 locations in six states and more than 500 employees, MB2 Dental customized services take in human resources, accounting and finance, compliances, marketing, recruiting, billing and collection and more.Dr. Akhil Reddy, who owns part of the company and is a leading practitioner, said his years of dental experience are also a factor in MB2 Dental. With just about 10 years dental experience, Dr. Reddy practices general dentistry in Texas. He graduated with a B.S. degree from the University of the Pacific and went on to earn his Doctor of Dental Surgery degree. His work includes diagnosing and treating oral health problems, providing teeth cleaning, cavity fillings, and root canal procedures as well as cosmetic dentistry.

According to a story at (, to conduct a dental practice productively, Dr. Reddy pointed out how impactful business skills as well as years of experience will be necessary for the practice to thrive. He gave the example of how making use of the staff expenditures service can prevent problems with overpaying or underpaying employees.Dr. Reddy, who has always loved mentoring and guiding dentists early in their careers, remarked in a story which can be found at how truly being thoughtful about his employees, but at the same time not developing into a best friend connection, is one approach that has made it easier for him to strengthen his business. He also said respect as well as accepting the distinctive requirements of individuals are essential for attaining positive growth.

According to Dr. Reddy, to bring about new ideas and concepts, he utilizes a general business strategy combined with strength, weakness, the right set of circumstances and risk review. He then consults with friends and collaborators for additional feedback. He also talked about a hardship he encountered running his own practice early in his career and how he had to sell it. On a more positive note he added the lessons he learned still benefit him in the present day as well as assist him in helping others.Dr. Chris Villanueva established MB2 Dental Solutions in 2009 as a means of making business solutions available to dentists so they can focus on the basics of their practices.

Dr. Weisfogel’s name comes to mind relative to the Dental Sleep Masters’ program. Dr. Weisfogel, throughout his distinguished career, has been working, diligently, in locating preferred remedies as it applies to sleep disorders. The sleep disorder of sleep apnea is serious. It is going undiagnosed to a high-degree. What the Dental Sleep Masters’ program intends to accomplish, is to introduce health professionals to this most serious health concern. The program is relative in that it allows the medical professional to clearly identify patients, possessing the possibility of having the disorder. It is important, according to Dr. Weisfogel, that the sleep disorder is addressed, as soon as possible. The condition leads to more serious health threats such as cardiovascular disease and diabetes.

When the healthcare provider partners with the team members at Dental Sleep Masters, he or she is providing his local healthcare community and the local populace, in general, with a much needed public service. As a bonus too: he or she is adding a revenue stream to his or her practice.

Notes Regarding Dr. Avi Weisfogel:

Dr. Avi Weisfogel co-founded the Dental Sleep Masters’ program. The company is located within South Orange, N.J. He established the organization in April of 2014. He co-founded the Dental Sleep Masters Company, along with two other Dental colleagues. The concept of the program is to allow healthcare providers to identify prospects who possess a sleep disorder—specifically that of obstructive sleep apnea. The remedy, with regard to sleep apnea, is an oral appliance.

Dr. Weisfogel, prior to his ownership of Dental Sleep Masters, lectured and educated, dentists on how to bring in more patients, into their respective practices, by way of establishing a sleep program. He has worked with hundreds of dentists and physicians, located throughout the country, in way of properly establishing and running a sleep lab.