Oncotarget is a free to access online journal that tackles various scientific researches and results. It is published weekly by the Impact Journals. It is also accessible in print upon special requests. The journal’s mission is to ensure scientific findings reach to as many people as possible. What the journal publishes is always reviewed by other peer scientists, a strategy that makes the information reliable. By being an online journal, the information is shared quickly ensuring that it is timely in fighting diseases. Oncotaget has managed to bridge the gap between different sectors while allowing all researchers to contribute to the growth of science by Mikhail Blagosklonny. The organization’s ultimate goal is for everyone to live in a world that is free of diseases.
Diet Restriction for Cellular Rejuvenation
One of the papers published by Oncotarget is on the nutritional perspective on cellular rejuvenation. Lifespan can be extended and aging process decelerated by restricting dietary energy intake. Most people confuse dietary restriction with calorie restriction. The two, however, have some significant differences. Dietary restriction involves decreasing the amount of food allocated. Calorie restriction means altering the nutritional composition thereby reducing the energy component of the food. In the study, mice fed on dietary restriction were let to undergo some fasting periods. These periods are believed to have effects on the extension of the lifespan. During fasting, the nutrient-sensing anabolic pathway is deactivated, which is a reason for lifespan prolonging effect. The indicator in play here is the inhibition of mTOR activity.
mTOR is a pathway that promotes growth, which is triggered by the circulation of amino acids, insulin, and other growth factors. It, however, inhibits autophagy and enhances metabolic derangement, counteracting cellular cleansing. mTOR hyper activation can, however, cause aging. On the other hand, overeating, ad libitum feeding, can grow an aging phenotype as evidenced by mice that were obese after being overfed. The accelerated aging was also seen after feeding them with diets that had more energy. The use of diet restriction on a diet- induced obese mice caused an abolishment of the mTOR pathway. The chaperone-mediated autophagy that usually declines with age was also induced. The end finding was that diet restriction leads to cellular rejuvenation.